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Silk fibroin membrane surface of the plasma acid and in vitro anticoagulant properties of
: 17 [2: DemuraM, AsakuraTBiotechnolBioeng, 1989,33:598 [3] MinouraN,ugg boots billig, TsukadaM, NaguraM. Polymer, 1990,31:265 l4] MinouraN, AibaSI, HiguchiM. eta】 BiochemBiophysResCorn. 1995.208; 511 [5lnouyeK, KurokawaM, NishikawaS, eta1. JBioctwmBiot,ugg prezzo, aysMethods. 1998,37:159:6 ChenJ, MinouraN,ugg milano, TaniokaAPolyrn ~, 1994,35:2853 l7] LinJc, CooperSL. Biomaterials,rosetta stone for sale, 1995,16 {1017 [8l ~ agaldN, TasakaS. MiyazakiH. 』ApplPolySci. 1989,38:1829 [9: Wang Xiufen, Zhu He-Sun Beijing University of Technology, 1999,19:250 [10JMinouraN, TsukadaM, NagaraMBiomaterials, 1990.11:43011] LinJC. CooperSLBiomaterials, 1995,16:1017 [12] Chang Chun Gui translation of foreign silk, 1997,4; 34 【13] FauziaMD. etalJThrombosisandThrombolysis, 1998,5:83 [14] KangTk,rosetta stone cheap, KwonOH, ByunKH. JofMaterSci: MaterinMed, 1996,7:13515 JSunYH, FengLx. JApplPdySci, 1999.74:2826 SurfaceSulfonationofSilkFibroinFilmbyPlasmaTreatmentandinvitroAntithrombogenicityGuJinwei, YangXinlin, WangLiyong, ZhuHesun (ResearchCenterofMaterialsScience, BeijingInstituteofTechnology, Beijing100081) AbstractBombyxmorisilkfibroin (SF) filmwastreatedbyplasmaprocesseswithSO2gastOintroducefunctionalgroupsonthesurfaceoffilm. Meanwhile, functionalgroupswerealsointroducedbythereactionof1 ,3-propanesultonewithaminesitesonthesurfaceofsilkfibroinfilmwhichwereproducedbyNH] gasplasmaXPSandATR-FTIRwereusedtOanalyzethesurfacechemicalelements. Theinvitroantithrombogenieitywasdeter-minedbythemethodofAPTT. TTandPTtest. Itwasshownthatsulfoniegroupwascovalentlygraftedonthesurfaceofthefilmsafterbothkindsoftreatments. andtheantithrombogencityofthefilmswasincreasedremarkablyduetothesurfacesulfonation. Keywords: Silkfibroin. Plasma. Antithrombogenicity
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