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necatabolicpatterninneuropsychiatficdisorders [J]. NeuralIndia, 2000,48 (3) :231-238. (Received :2007-12-26) imipramine in the treatment of depression combined spearheading the clinical observation for Liling Cai Sheng Li Jie Chang-Lin Lan Kim Mi 【Key Words】 R749.4; R749.053】 【Document code B】 【Article ID 1007-3256 (2008) O2-0079-01 In this paper, spearheading the merger of imipramine and imipramine alone in the treatment of depression and compared the efficacy and safety. Are reported as follows: 1 1.1 objects are objects and methods in our hospital outpatient clinic or hospitalized patients, in line with the Chinese Classification and Diagnostic Criteria of Mental Disorders Third Edition (CCMD-3) diagnostic criteria for depression; TCM is and the 6o patients were randomly divided into two groups: imipramine combined spearheading the group (combined group) were 3O cases, including 14 males and 16 females; aged 18-56 years, mean (39.3 ± 14. years of age; duration 2-36 months, mean (4.7 ± 5. months. 3O imipramine group of patients, male I1, female 19 cases; aged 19-56 years,[link widoczny dla zalogowanych], mean (38.9 ± 15.2) years; course of 2 to 38 months, the average (4.7 ± 5.6 months). The above two groups were not significantly different (P all> 0.05). I. 2 Methods initial dose of imipramine 50mg / d, 2 weeks, increased to 200mg / d. Spearheading 30rid, without content. Such as poor sleep may be taking benzodiazepine medicines. With Hamilton Depression Rating Scale (HAMD) and adverse reactions Scale (TESS), respectively, before and after treatment in the treatment of the first weekend of each score 1,2 ... 468 1, scale by 2 or more psychiatric staff physician evaluation,[link widoczny dla zalogowanych], consistency test Kappa = 0.82. HAMD efficacy evaluation by reducing rate 75% recovery. Before and after treatment in the treatment of examination of blood, urine, liver function, electrocardiogram, and records of adverse reactions. Statistics by f test and inspection. 2 Results 2.1 Comparison of two clinical doses of imipramine in the treatment groups were 200mg / d. Imipramine combined spearheading the group from 6 to 12 days markedly, the average (6.8 ± 3.4) d; imipramine alone group was 14-2O days markedly, the average (12.2 ± 7.6 ) d, the former markedly earlier, and there was significant difference (f = 4.09, P 0.05). 2.2 HAMD scores between the two groups before and after treatment (see table). Schedule HAMD scores before and after treatment in both groups (± s) from the Schedule, other than the l-week, the two HAMD score was no significant difference (P> 0.05). 2.3 The combined group of major adverse side effect was constipation in 11 cases,[link widoczny dla zalogowanych], dry mouth 1O cases, 6 cases of tachycardia, and 1 week of treatment were significant, then gradually reduce and disappear. Imipramine group and 15 cases of constipation. Dry mouth in 12 cases, 8 cases of tachycardia, arrhythmia termination of treatment in 1 case. 3 Discussion imipramine for the tricyclic antidepressants, the main pharmacological effect is inhibition of NE and 5HT neurons to recovery,[link widoczny dla zalogowanych], and thus play the utility of antidepressant .... Medicine spearheading the white peony root, angelica root, Poria, licorice, from surgery, Bupleurum, ginger, mint and other components,[link widoczny dla zalogowanych], with liver qi stagnation, spleen, nourishing the effect, for the clinical syndrome is a type of disease a significant effect, two-drug combination treatment on the onset of depression early, adverse reactions, and imipramine combined spearheading the treatment of depression better than imipramine alone.
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