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Excessive fluoride during development of rat incisor Smad3 expression


Protein,[link widoczny dla zalogowanych], formation and mineralization in dentin played an important role in regulating . The experiments show that Smad3 in the normal development of rat incisor secretory and maturity were strongly positive expression, suggesting that Smad3 in the enamel matrix secretion and mineralization ; Smad3 in the odontoblast layer was positive ,[link widoczny dla zalogowanych], and more to the cut end The direction of the stronger expression of Smad3 ,[link widoczny dla zalogowanych], which is TGF. Basically the same expression pattern of Bl , suggesting that Smad3 involved in TGF. Bl on odontoblast differentiation and dentin matrix secretion regulation. Excessive fluoride in the experimental group during development of rat incisor inhibit the expression of Smad3 ,[link widoczny dla zalogowanych], the gray value of the experimental group were significantly higher , statistically significant difference test , indicating that Smad3 in ameloblasts and into the teeth Cells decreased the expression of the essence . It is reasoned that fluoride may inhibit the expression of Smad3 affecting TGF-13/Smads signal transduction pathway ,[link widoczny dla zalogowanych], interference between epithelial and mesenchymal abnormal signal transduction , thereby inhibiting the ameloblasts and odontoblasts differentiation And the subsequent synthesis and secretion of matrix and mineralization. This may be occurring dental fluorosis intracellular mechanism . . - O
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