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: 68 cases of asthma were divided into two groups, respectively, combined with sand T alcohols furosemide and salbutamol therapy alone, compared to efficacy. Results: The increase in lung function and symptoms were signs of improvement than the control group. Conclusion: Furosemide in the treatment of bronchial asthma has an important role,[link widoczny dla zalogowanych], a higher efficacy and safety. Key words salbutamol; Furosemide; atomization; Asthma Article ID :1009 -5519 (2006) 12-1833-02 CLC number: R5 Document code: B bronchial asthma (the asthma) is a chronic gas inflammation, characterized by reversible airway obstruction and airway hyperresponsiveness. Our hospital with salbutamol inhalation United Furosemide treatment of asthma in 68 patients with satisfactory outcome, are reported as follows: 1 Data and method 1.1 Case Selection: 68 patients with 16 to 69 years old with moderate to severe asthma (FEV1% in 30 % ~ 50%),[link widoczny dla zalogowanych], reversible greater than or equal to 15%. Heart, liver function was normal. Without systemic infection or severe respiratory tract infection. 68 patients were randomly divided into treatment group (33 people) with the control group (35 persons), control group 18 men. L7 women, aged (32.5 ~ 11) years, mean asthma duration (14.5 ~ 11.2) years, FEV1 in people's homes to (1.82: t: 0.14) L, FEV1 is ( 45.6 ~ 4.3)%. 17 treatment group and 16 women,[link widoczny dla zalogowanych], aged (33.5 ~ 11.6) years, the average mean asthma duration (15.5 to 12.3) years, FEV1D in the admission of (1.78 ~ 0.13) , FVE1 is (43.9 5.4)%. Both groups were generally comparable. 1.2 Drug: salbutamol solution (trade name all tnine) from 葛兰索威康 Chinese companies,[link widoczny dla zalogowanych], each with a capacity of 20fnl. Furosemide Xinzheng by Tianjin Pharmaceutical Holdings Limited, 20ms / support. 1.3 Test Method: Before the test, detailed history, physical examination and laboratory tests carried out, the Church of patients inhalation method. All patients were given oxygen, antibiotics, expectorants, anti-inflammatory application of methylprednisolone, aminophylline and asthma, on this basis, treatment group salbutamol solution 2ml (10mg), 1 Furosemide Support (2Omg) plus normal saline 4m1. After the shoot out with a syringe of people GZ-I-type jet nebulizer medical plastic, by 6 ~ 8L/min the atomizing inhalation 1O ~ 2O minutes, every 8 / b 1 when inhaled,[link widoczny dla zalogowanych], a total of 5 days. In addition to the control group is not used outside Furosemide. The other with the treatment group were the same. Instruct patient registration cough, wheeze, activity limitation, sleep disturbance and so on. 1.4 Statistical Methods: t test. P <0.05, was considered statistically significant. 2 Results 2.1 after 5 days in the treatment group significantly increased FEV1 in patients in the control group increased slightly. The difference between the two groups was significant. Treatment group, 24.2% of patients improve the value of FEV1 over 45%, 5.7% in the control group, treatment group 69.7% of patients improved FEV1 values ​​of 20% to 45%, while the control group only 57.1% (P <0. 01). 2.2 Change of symptoms before and after treatment: the treatment group improved more than the symptoms of patients was 96.9%. The control group was 77.1%. Symptoms worsen, the treatment group was 3.1%, 14.3% in the control group. Far better than treatment group than the control group. 3.2 The two groups were not found in the atomization process adverse reactions. 3 Discussion asthma is caused by various cells (such as eosinophils, mast cells, T cells, neutrophils, airway epithelial cells) and cellular components involved in chronic inflammatory airway diseases. Such chronic inflammation leads to increased airway reactivity, usually reversible with widespread variable airflow limitation, and cause recurrent episodes of wheezing, shortness of breath, chest tightness or coughing and other symptoms 『l1. Airway inflammation can cause damage to airway epithelium, epithelial shedding. Xiao violence nerve endings so that airway epithelial damage caused by ultra-sensitive cholinergic neurons in the state. And induce airway hyperresponsiveness (AHR), airway epithelial damage to airway mucosal cilia clearance decreased or disappeared, resulting in a variety of inhaled irritants can not be discharged in time and deposited in the airway mucosal surface. So that the airway in the and cell exudation increased, increased epithelial cell function degeneration or necrosis. So that the inflammation increases Orioles, increased airway responsiveness. In the process of airway inflammation in a variety of inflammatory mediators and cytokines in response to the interaction leading to airway
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